Is Melatonin Safe ?


Is Melatonin Safe? research data shows that melatonin can be considered as one of the chemicals that are least toxic. Some people have taken as high as 7 grams which is 600 to 3,000 times compared to the normal dosage. There are only four complaints to the FDA (US Food and Drug Administration) with regards to the use of melatonin. The most common Melatonin side effect is drowsiness and a slower reaction time when it comes to daily activities. A study in Netherlands involving 1,400 women, which was given 75mg of Melatonin for up to 4 years reported no ill effects.

According to current research, you are safe to take melatonin if you are:

  • more than 18 years old, and healthy
  • you are not pregnant
  • you are not breast-feeding
  • you are not taking other drugs except for minor analgesics

As general rule, You should not use melatonin unless under a medical doctor’s supervision if:

  • You are working as a pilot, railroader, trucker or you have an occupation in which the lack of alertness on the job could endanger you and others.
  • You are operating heavy machinery
  • You are suffering from migraine headaches
  • You are suffering from depression or have a family history of depression
  • You are suffering from eye disease, such as retinitis pigmentosa

Is Melatonin Safe for Children?

Melatonin for children is safe and effective when used for short periods of time. However, parents should consider other methods in making their kids sleep faster. You can train your kids to avoid watching TV before bedtime and avoiding caffeine. Melatonin is a hormone and the long term safety of its use is still uknown. There are also no data about long term side effects on children.

Melatonin References:

Webb SM, Puig-Domingo M. Role of melatonin in health and disease. Clin Endocrinol . 1995;42:221-234.

Cowley G. Melatonin. Newsweek . 1995;Aug 7:46. laustrat, B., Brun, J., David, M., Sassolas, G., & Chazot,
G. (1992).

Melatonin and Jet Lag: Confirmatory Result Using a Simplified Protocol. Biological Psychiatry, 32,
705-711.

Jan, J. (1994). The Treatment of Sleep Disorders With Melatonin. Developmental Medicine and Child Neurology, 36, 97-107.

Lino, A., Silvy, S., Condorelli, L., & Rusconi, A. (1993). Melatonin and Jet Lag: Treatment Schedule. Biological Psychiatry, 34, 587.

Zhdanova, I. (1995). Sleep – inducing effects of low doses of melatonin ingested in the evening. Clinical Pharmacology & Therapeutics, 57, 552-558.

Arendt J. Melatonin. Clin Endocrinol . 1988;29:205-229.

Borbely AA. Commentary on the articles by Arendt, Weaver, Mahle, et al, and Guardiola-Lemaitre. J Biol Rhythms . 1997;12:707-708.

Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo. Biol Signals Recept 2000 May-Aug; 9(3-4):160-71.

Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines. J Pineal Res 2000 28(4):227-33.

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