Melatonin and Valerian


Melatonin and valerian both have the ability to treat insomnia and migraine. Sometimes valerian is recommended for treating anxiety and stress. Melatonin has other possible applications; you can use melatonin for treating jet lag, sleep disorders, seasonal affective disorder, tardive dyskinesia, epilepsy, fibromyalgia and glaucoma. Melatonin may also help decrease the side effects of chemotherapy as well as drug withdrawal. Melatonin may also be useful in cancer treatment and HIV/AIDS treatment. There is no conclusive medical evidence that supports the use of melatonin supplements or valerian supplements in the treatment or prevention of any disease.

Valerian is harvested from the dried roots and other parts of the Valerian plant. It is generally used for the treatment of sleeping disorders, anxiety, headaches and panic attacks. Valerian was first introduced in tea form but it became available in pill and liquid form. Valerian is now widely available as a dietary supplement and sold over the counter in most countries. The side effects of valerian use include mild depression, dizziness, agitation, anxiety, allergic reactions and in worst cases, liver failure. Sometimes valerian is by pregnant or lactating women. The effect of valerian on the unborn child is still unknown. Valerian should not be taken by people who are taking medications for allergy, cancer, cholesterol and fungus. Melatonin side effects range from Sleepiness during daytime, Feeling Dizzy, Headaches, Gastric disturbance and abdominal discomfort, Confusion, Sleepwalking, Vivid dreams or Vivid Nightmares and Mental or Mood Changes.

Can I take Valerian and Melatonin at the same time?

Melatonin and Valerian can be used both as natural sleeping aids and they are sold as food supplements in health shops. The safety record of both melatonin and valerian is also good but these food supplements should not be taken at the same time. Taking valerian and melatonin together may give you heavy drowsiness, confusion, nausea and headaches.

Melatonin and Valerian References:

Bent S, Padula A, Moore D, Patterson M, Mehling W. Valerian for sleep: a systematic review and meta-analysis. Am J Med. 2006 Dec;119(12):1005-12.

Bliwise DL, Ansari FP. Insomnia associated with valerian and melatonin usage in the 2002 National Health Interview Survey. Sleep. 2007 July 1;30(7):881-884.

Kamel NS, Gammack JK. Insomnia in the elderly: cause, approach, and treatment. Am J Med. 2006 Jun;119(6):463-9.

Mindell JA, Emslie G, Blumer J, Genel M, Glaze D, Ivanenko A, et al. Pharmacologic management of insomnia in children and adolescents: consensus statement. Pediatrics. 2006 Jun;117(6):e1223-32.

Mindell JA, Kuhn B, Lewin DS, Meltzer LJ, Sadeh A; American Academy of Sleep Medicine. Behavioral treatment of bedtime problems and night wakings in infants and young children. Sleep. 2006 Oct 1;29(10):1263-76.

6 Responses to Melatonin and Valerian

  1. m. sullivan says:

    My husband has social anxiety disorder, ocd, depression and has been diagnosed also with bipolar disorder. He has been taking melatonin for insomnia and now takes smaller doses throughout the day for anxiety, etc. It has helped tremendously, but lately has been having trouble with vivid dreams, waking up disoriented and sleep walking. Last night he got up and fell flat on his face, cutting the inside of his mouth…i found him face down in a pool of blood. this morning he didn’t remember any of it. May have to go back on rx meds…doctor’s advice.

  2. doug says:

    I take them both all the time. aint buyin the B.S. sorry folks. Sure, ask your doctor first, then when he’s/she’s done looking them up in the dictionary, he/she can give you their (professional opinion).

  3. Sandi Scott says:

    Is it safe to take melatonin with Apo-Ramipril, Apo Metoprolol L, Jamp ASA EC and Lipito?

    • admin says:

      the only reference we have between blood pressure lowering drugs and melatonin states that melatonin may lower the effectiveness of those drugs.

      it might not be a good idea to mix melatonin with blood pressure lowering drugs specially if you have very high blood pressure.

  4. Michelle says:

    I take melatonin, valerian root and 5 htp at the same time every night. It has helped me so much. I was not sleeping and had moderate to severe depression. (The doctor put me on wellbutrin and ambien, but didn’t do well on it.) Since taking this combo I have been sleeping very well every night, feel well rested in the morning, depression has literally gone away. Some side effects I have had are the vivid dreams and occasionally sleepy during the day although not enough for me to want to nap. My only question about this is how long can I take these for?

    • admin says:

      there has been no studies conducted about the long term side effects of Valerian and Melatonin. We can only speculate about the long term effects of those supplements. For melatonin, there was one research that it was generally safe for about 3-4 years of continuous use.

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