Melatonin drug interactions


Melatonin is also known to affect the action of some prescription medications. There are also drugs or substances that affect the production of melatonin. Melatonin may not be used by some persons, it depends on their current medical condition and the type of medication they are taking. Melatonin side effects maybe aggravated by certain medications too.

Antidepressant Medications – Animal studies show a reduction in the antidepressant effects of fluoxetine and desipramine. There is still a need for additional research to see if the same effects would occur in people. The use of Fluoxetine (a member of SSRIs) also leads to depletion of melatonin in people.

Interleukin-2 – In a study involving 80 cancer patients, the use of melatonin supplements with interleukin-2 led to increased regression of tumor and higher survival.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) – NSAIDs like ibuprofen may reduce melatonin levels in the blood.

Steroids and Immunosuppressant Medications – Corticosteroids and other drugs used to suppress the immune system should not be mixed with the use of melatonin supplements. The use of melatonin may render those drugs ineffective.

Tamoxifen – Preliminary data suggests that combining Tamoxifen (chemotherapy drug) and melatonin may benefit patients suffering from breast cancer and other forms of cancer. Additional is research is needed for confirmation.

Antipsychotic Medications – Melatonin supplements can significantly reduce Tardive Dyskinesia, a common side effect of taking antipsychotic medications.

Benzodiazepines – Melatonin with Triazolam is shown to improve sleep quality in one study. There are also reports that melatonin supplements can actually help individuals to stop the long term use of benzodiazepine.

Blood pressure medications – the effectiveness of blood pressure medications like methoxamine and clonidine may be reduced by melatonin supplements.

Calcium Channel Blockers (another type of blood pressure medications) can decrease melatonin levels. Some examples of calcium channel blockers are nifedipine, nimodipine, felodipine, nisoldipine, verapamil, diltiazem, amlodipine and bepridil.

Beta Blockers (another type of blood pressure medications)may also decrease the production of melatonin in the body. Some examples of beta-blockers are propranolol, pindolol, nadolol, sotalol, acebutolol, atenolol, labetolol, metoprolol, and timolol.

Blood-thinning medications, Anticoagulants – Melatonin may increase the chances of bleeding from anticoagulant drugs like warfarin.

Other Substances – Tobacco, caffeine and alcohol can all decrease melatonin levels in the body while amphetamines and cocaine may increase melatonin production.

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15 Responses to Melatonin drug interactions

  1. Angel says:

    My son is 15 and takes 50 mg. of Zoloft for Major Drepressive Disorder. He is having problems with falling asleep at school during the day. His doctor told me to give him 3 mg of Melatonin at night to help him sleep. Is this safe for him? Weight 108 lbs., height 5’2.

  2. michele gardner says:

    I take 3 4mg of Melatonin at night about once a week. I also take100mg of metoprolol trate and Carisoprodol 350 mg is this ok? I take the last mediciene for neck pain.

  3. Cheryl says:

    My doctor recommended Melatonin – 5mg. I am also taking ibuprofen 800mg and a low dose (0.035) hormone replacement medication prescribed by the same physician. Should I be worried? Any known negative drug interactions with Melatonin and hormone replacement Meds?

  4. Megan says:

    I have taken Melatonin before and it has worked wonderfully! But now i am on Byetta, Tenuate, Spiranolactone, and Lexapro for PCOS. I really have trouble staying asleep, but am kind of apprehensive about adding Melatonin to my regimen. Anny suggestions?

  5. Judy Mitchum says:

    I take Lipitor for cholesterol and Zoloft for anxiety and depression. I would like to try Melatonin but do not know if there are any drug interactions with these 2 medications. Could someone please answer this qoestion. I am having a horrible time sleeping at night. I am awake for at least 2 hours after going to bed.

    • Judy, age & weight not mentioned. You can stop lipitor & instead correct your diet & do moderate exercises daily. Can stop Zoloft, know what is causing anxiety & depression & try to eliminate those causes or forget about them & start meditation. U can take Tb Melatonin 3 mg. at bed time & combine it with meditation. However your present medication can be continued along with melatonin as it is naturally secreted hormone. Vitamin deficiencies has to be corrected if they exist as it can cause depression. Keep in mind melatonin is just like youth hormone.

  6. ron says:

    I take clonopin and symbalta , I have been taking melatona to help me to sleep as welll, I have anxeity, I didn’t feel any side effects taken with those other drugs and i did a ramdon sugar test and that was also fine. I did have some constipation , but I ake up feeling great.

  7. Tom says:

    Is there any drug interactions with Anticonvulsants such as Carbamazepine, Tegretol, Esliacarbamazepine Acetate?

    I am in a research study with Esliacarbamazepine Acetate and took
    one 10mg time release melatonin before bed. The next day I had two very small seizures a few hours apart. I usually only have one or two a week.
    I have complex partial epilepsy. http://en.wikipedia.org/wiki/Complex_partial_seizure

    Hmm.. Maybe I already have answered my question!

  8. sonia lefrancois says:

    i have troubles falling asleep at night and sometimes just lay there for hours after i go to bed, so i bought myself some time release Melatonin 2mg. It worked! I had a restful sleep and i fell asleep right away. I’m concerned though because I have pain and stiffness in my shoulder and neck so sometimes i also take either an ibuprofen 400mg or a Tylenol3, should i be taking the pain med and the Melatonin together at night or not?

  9. Fred says:

    I have been supplementing Ambien with melatonin for sleep. I am also under treatment for high blood pr3essure with Norvasc. For more than a year I have used a low dose of melatonin, about 1 mg, with no evident effect on my blood pressure. However, I doubled the dose because of mid night wakefulness, and was horerified to see my blood pressure increase to 188/95. If I use melatonin it will be below 1 mg. [Ambien alsone is less effective for sleep.]

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