Melatonin drug interactions


Melatonin is also known to affect the action of some prescription medications. There are also drugs or substances that affect the production of melatonin. Melatonin may not be used by some persons, it depends on their current medical condition and the type of medication they are taking. Melatonin side effects maybe aggravated by certain medications too.

Antidepressant Medications – Animal studies show a reduction in the antidepressant effects of fluoxetine and desipramine. There is still a need for additional research to see if the same effects would occur in people. The use of Fluoxetine (a member of SSRIs) also leads to depletion of melatonin in people.

Interleukin-2 – In a study involving 80 cancer patients, the use of melatonin supplements with interleukin-2 led to increased regression of tumor and higher survival.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) – NSAIDs like ibuprofen may reduce melatonin levels in the blood.

Steroids and Immunosuppressant Medications – Corticosteroids and other drugs used to suppress the immune system should not be mixed with the use of melatonin supplements. The use of melatonin may render those drugs ineffective.

Tamoxifen – Preliminary data suggests that combining Tamoxifen (chemotherapy drug) and melatonin may benefit patients suffering from breast cancer and other forms of cancer. Additional is research is needed for confirmation.

Antipsychotic Medications – Melatonin supplements can significantly reduce Tardive Dyskinesia, a common side effect of taking antipsychotic medications.

Benzodiazepines – Melatonin with Triazolam is shown to improve sleep quality in one study. There are also reports that melatonin supplements can actually help individuals to stop the long term use of benzodiazepine.

Blood pressure medications – the effectiveness of blood pressure medications like methoxamine and clonidine may be reduced by melatonin supplements.

Calcium Channel Blockers (another type of blood pressure medications) can decrease melatonin levels. Some examples of calcium channel blockers are nifedipine, nimodipine, felodipine, nisoldipine, verapamil, diltiazem, amlodipine and bepridil.

Beta Blockers (another type of blood pressure medications)may also decrease the production of melatonin in the body. Some examples of beta-blockers are propranolol, pindolol, nadolol, sotalol, acebutolol, atenolol, labetolol, metoprolol, and timolol.

Blood-thinning medications, Anticoagulants – Melatonin may increase the chances of bleeding from anticoagulant drugs like warfarin.

Other Substances – Tobacco, caffeine and alcohol can all decrease melatonin levels in the body while amphetamines and cocaine may increase melatonin production.

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